Antibiotics as the fastest way to get rid of bacterial infection
Antibiotics belong to the highly active antibacterial drugs, firmly established in the medical practice. The drugs of this group can be considered as broad-spectrum antibiotics. It should be noted that the drugs of this group have different pharmacokinetic properties and specific antibacterial activity. They are available in the form of pills and solutions for injection. Antibiotics can be purchased both in a drugstore and in the online pharmacies with delivery to your door.
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Antibiotic mechanism of action
Due to their structure and mechanism of action, antibiotics have a high bactericidal activity, compatible with the third-generation cephalosporins. The drug is effective against gram-negative and gram-positive microorganisms, including strains, resistant to other antibacterial drugs and atypical intracellular pathogens.
Antibiotics have an optimal pharmacokinetic profile and are well absorbed in the digestive tract (about 100%). The rapid penetration into the tissues at the site of infection creates high concentration of the drug. The half-life of the drug is 5–7 hours.
Antibiotics can be taken together with many antibacterial preparations (macrolides, b-lactam antibiotics and cephalosporins). Due to this property, the drug is widely used as part of a combination therapy of infectious diseases. In contrast to ciprofloxacin, antibiotics remain active if you combine them with RNA polymerase inhibitors (chloramphenicol and rifampicin).
Antibiotics online belong to the group of tricyclic monofluoroquinolone. In contrast to ciprofloxacin, it is hardly metabolized in the liver. The bioavailability of antibiotics in case of oral and parenteral administration is identical. Due to this, when changing the injection way of administration to the oral one, the dose adjustment is not required (which is one of the most important differences between antibiotic and ciprofloxacin).
It easily penetrates into the target organs (for example, in the case of chronic prostatitis — into the prostate tissue). It should be noted that, in case of prostatitis, prostatic capsule is practically impenetrable for many antibacterial drugs.
Linear relationship between the dose of antibiotic and its concentration in tissues.
Antibiotics should be taken once or twice a day. Food intake doesn’t affect the absorbability of the drug. However, if you eat fat food, the absorption of antibiotics slows down.
Antibiotics interacts with other drugs to a lesser extent than ciprofloxacin. It has little or no impact on the kinetics of theophylline and caffeine and sodium benzoate.
Antibiotics are excreted mainly by the kidneys (over 80%) in an unchanged form, i.e. this drug doesn’t have an effect of primary passage through the liver. The concentration of antibiotics in feces is much lower than that of the other drug components. However, this drug is more effective for the treatment of bacterial and traveler’s diarrhea. This is attributable to its more pronounced activity to staphylococci and salmonella. Antimicrobial activity of antibiotics is most expressed in relation to gram-negative bacteria and intracellular pathogens (chlamydia, mycoplasma and ureaplasma); however, antibiotics are less active against streptococci and blue pus bacillus.
Bactericidal efficacy of antibiotics manifests itself quickly enough, and the resistance of microorganisms to this drug develops rarely. This is due to its bactericidal mechanism of action affecting only one gene of DNA. gyrase and topoisomerase.
In clinical practice, antibiotics are a drug of choice or alternative first-line drug. It is recommended for empirical therapy of many urogenital infections. Due to the good tolerability (the frequency of side effects is 1.3%), high bioavailability of the pills and optimal spectrum of action (it is active against 94% pathogens, causing urogenital infections, apart from the simplest and anaerobic infections) it can be used on an outpatient basis. A significant advantage of antibiotics in the treatment of urinary infections is its high concentration in the renal parenchyma and pelvic plating system.